Southampton fired manager Nathan Jones on Sunday after a 2-1 loss to Wolverhampton a day earlier that left the team in last place in the Premier League.
Fans called for Jones to be sacked as Soton conceded two late goals against an opponent playing with 10 men for more than an hour.
The club made the announcement barely three months after Jones took charge as the replacement for Ralph Hasenhuttl.
“Southampton Football Club can confirm it has parted company with Men’s First Team Manager Nathan Jones,” the club said.
Jones’ first team coaches Chris Cohen and Alan Sheehan have also departed.
Southampton lost seven of its eight league games under Jones, whose best results have come in the domestic cups.
The saint reached the English League Cup semifinals after beating Manchester City in the quarterfinals.
Southampton said coach Rubén Sellés would take charge of training and preparations ahead of its next game against ChelseaAMP next weekend.